Your starting point is your e-mail address. You can very simply access it through the webmail interface.
You can change your password and alter a few settings at the mailbox settings page.
Your e-mail client (such as Thunderbird) needs a little information so it can fetch your mail. Always use:
Receiving messages is done with the IMAP protocol. Point your software to the server address imap.dreamhost.com. Make sure you are using SSL encryption (you may have to set the port to 993).
Sending messages is done over the SMTP protocol. Point your software to the server address smtp.dreamhost.com. Make sure you are using SSL encryption (you may have to set the port to 465).
More information is available over there.